FAMILIA INTERLEUQUINA 1

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La interleuquina 1 (IL-1) o interleucina 1 es una citoquina crucial en el sistema inmunológico y desempeña un papel central en la respuesta inflamatoria del organismo. Es una proteína de señalización celular, que regula diversas respuestas inmunológicas y proinflamatorias en el organismo, realizan dicha función uniéndose a receptores primarios del tipo: IL-1 RI/IL-1 R1, IL-18 R alfa/IL-1 R5, IL-1 Rrp2/IL-1 R6, o ST2/IL-1 R4, para posteriormente mediante un receptor accesorio (co-receptor) formar complejos de receptor activos. La interleuquina 1 es producida por distintos tipos de células, especialmente por macrófagos activados, pero también por monocitos y células dendríticas. Se produce en grandes cantidades como respuesta a infecciones, lesiones o estrés. Se trata de un mediador clave en la respuesta inflamatoria provocando fiebre, aumento de los neutrófilos circulantes y producción de proteínas de fase aguda. Codificada en el cromosoma 2, históricamente fue una de las primeras citoquinas descubiertas

Liberación de Il-1

La interleuquina 1 es liberada como respuesta al TNFα. Se conocen tres formas:

  • La IL-1α principalmente intracelular.
  • La IL-1β que, secretada a la circulación, interacciona con dos tipos de receptores de Tipo I (en la mayoría de las células), y de Tipo II (en linfocitos B, neutrófilos, monocitos y células de la médula ósea)
  • La IL-1RA inhibe la unión de las dos primeras a sus receptores.

Funciones principales de la IL-1

  • Efectos proinflamatorios debidos a la liberación de histamina por los mastocitos, provocando vasodilatación e inflamación localizada.
  • Tiene actividad quimiotáctica sobre los granulocitos.
  • Tiene acividad pirogénica mediante la liberación de prostaglandinas.
  • Aumenta, junto al TNFα i la IL-6, las proteínas de fase aguda como el fibrinógeno y la PCR.
  • A nivel del SNC aumenta el sueño y la anorexia en procesos infecciosos (efecto del óxido nítrico).
  • Aumenta la liberación de hormonas hipofisarias.
  • Aumenta el número de células precursoras en la médula ósea.
  • Aumenta la expresión de los genes que la producen, y también de los que producen prostaglandinas, leucotrienos, IL-8 y algunos protooncogenes

La sobreproducción o la disfunción de la IL-1 se asocian con numerosas enfermedades inflamatorias crónicas, como la artritis reumatoide y la enfermedad inflamatoria intestinal

Clasificación

FAMILIAALIAS
IL-1αInterleukin-1 alphaIL-1F1, IL-1α, IL1α,IL-1 alpha,IL1 alpha,IL-1a,IL1a,IL1A
IL-1βInterleukin-1 betaIL-1F2, IL-1β, IL1β,IL-1 beta,IL1 beta,IL-1b,IL1b,IL1B
IL-1raInterleukin-1 Receptor AntagonistIL-1ra,IL1RA,IL-1RA,IL-1F3
IL-18Interleukin-18IL18,IL-18, IGIF, IL1F4,IL-1F4
IL-33Interleukin-33IL33,IL-33,C9orf26,IL1F11,IL-1F11
IL-36αInterleukin-36 alphaIL1F6, IL-36α, IL36α,IL-36 alpha,IL36 alpha,IL-36a,IL36a, IL36A, IL-36A,IL-1F6
IL-36βInterleukin-36 betaIL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8
IL-36γInterleukin-36 gammaIL1F9, IL-36γ, IL36γ,IL-36 gamma,IL36 gamma,IL-36g,IL36g,IL36G,IL-36G,IL-1F9
IL-36RaInterleukin-36 Receptor AntagonistIL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5
IL-37Interleukin-37IL-37,IL37,IL-1F7, IL-1F7, IL-1H, IL-23
IL-38Interleukin-38IL-38,IL-1F10,IL1F10,IL38

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