Human Interleukin-1 Family Member 10 (IL1F10) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Interleukin-1 Family Member 10 (IL1F10) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx258145
tested applications
ELISA
Description
Human Interleukin-1 Family Member 10 (IL1F10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin-1 Family Member 10 (IL1F10) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Interleukin-1 Family Member 10 (IL1F10) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 7.8 pg/ml - 500 pg/ml |
| Sensitivity | < 2.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL-38,IL-1F10,IL1F10,IL38 |
| Background | Elisa kits for IL1F10 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL1F10, also known as IL-38, is a member of the IL-1 cytokine family that plays an emerging role in immune modulation and inflammation control. IL1F10 binds to the IL-36 receptor (IL1RL2) and acts as an anti-inflammatory cytokine by antagonizing IL-36 signaling pathways. It inhibits the activation of NF-κB and MAPK, thereby suppressing the production of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-17. IL1F10 is expressed in immune cells, epithelial cells, and barrier tissues, including the skin, lungs, and gastrointestinal tract, where it regulates inflammation and maintains tissue homeostasis. It has been shown to counteract the effects of IL-36 agonists in diseases like psoriasis, inflammatory bowel disease, and rheumatoid arthritis, highlighting its protective role in chronic inflammation. IL1F10 also contributes to limiting immune hyperactivation during infections and autoimmune responses. Knockdown or reduced expression of IL1F10 exacerbates inflammatory responses, increases cytokine production, and worsens tissue pathology, emphasizing its function as a key anti-inflammatory cytokine and immune homeostasis regulator.
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