Dog Interleukin 1 Alpha (IL1a) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Dog Interleukin 1 Alpha (IL1a) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx150257
tested applications
ELISA
Description
Dog Interleukin 1 Alpha (IL1a) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog IL1A concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Interleukin 1 Alpha (IL1a)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Interleukin 1 Alpha (IL1a) |
| Reactivity | Dog |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 7.8 pg/ml - 500 pg/ml |
| Sensitivity | < 3.0 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL-1F1, IL-1α, IL1α,IL-1 alpha,IL1 alpha,IL-1a,IL1a,IL1A |
| Background | Elisa kits for IL1A |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL1A is a pro-inflammatory cytokine and a member of the interleukin-1 (IL-1) family, acting as a potent mediator of inflammation, immune responses, and tissue homeostasis. IL1A is produced as a precursor protein that can function in its membrane-bound or cleaved active form following cellular stress, necrosis, or damage. It signals through the interleukin-1 receptor (IL1R1) and its co-receptor IL1RAP, activating downstream NF-κB, AP-1, and MAPK pathways, which drive the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules. IL1A is primarily expressed by epithelial cells, keratinocytes, monocytes, and macrophages in response to infections, tissue injury, or inflammatory stimuli. It plays critical roles in host defense, fever induction, and leukocyte recruitment while also modulating tissue repair and homeostasis. Dysregulated IL1A activity contributes to chronic inflammatory diseases, cancer progression, and fibrosis. Knockout studies reveal impaired inflammatory responses, reduced leukocyte recruitment, and delayed tissue repair, highlighting IL1A's role in initiating inflammation, immune signaling, and maintaining tissue integrity.
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