Human Interleukin 1 Receptor Antagonist (IL1RN) Protein
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935106861
info@markelab.com
Precio
1326€ (1 mg)
Protein IL1RN
proveedor
Abbexareference
abx060248Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human IL-1R antagonist Protein is a recombinant Human protein.
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 1 Receptor Antagonist (IL1RN)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute with sterile 18MΩ-cm H2O.
tested applications
SDS-PAGE
size 1
1 mg
observerd MW
Molecular Weight: 22 kDa
expression
Recombinant
purity
> 95% (HPLC and SDS-PAGE)
buffer
10 mM phosphate buffer, 200 mM NaCl (pH 7.0). Does not contain preservatives.
storage
Store at -20°C or -80°C for 2 years. After reconstituting, it can be stored at 4°C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze/thaw cycles.
or code
IL1RN
dry ice
No
availability
Shipped within 5-10 working days.
alias
IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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