Human Interleukin-1 Family Member 10 (IL1F10) Protein

Este producto es parte de IL1F10 - Interleukin 38
Human Interleukin-1 Family Member 10 (IL1F10) Protein
715€ (50 µg)

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Name
Human Interleukin-1 Family Member 10 (IL1F10) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx655705
Tested Applications
WB, SDS-PAGE

Description

Human Interleukin 1 Theta (IL1q) Protein (Active) is an Active recombinant Human protein.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Interleukin-1 Family Member 10 (IL1F10)
Assay Type
Activity: Active
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
IL-38,IL-1F10,IL1F10,IL38
Background
Protein IL1F10
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

IL1F10, also known as IL-38, is a member of the IL-1 cytokine family that plays an emerging role in immune modulation and inflammation control. IL1F10 binds to the IL-36 receptor (IL1RL2) and acts as an anti-inflammatory cytokine by antagonizing IL-36 signaling pathways. It inhibits the activation of NF-κB and MAPK, thereby suppressing the production of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-17. IL1F10 is expressed in immune cells, epithelial cells, and barrier tissues, including the skin, lungs, and gastrointestinal tract, where it regulates inflammation and maintains tissue homeostasis. It has been shown to counteract the effects of IL-36 agonists in diseases like psoriasis, inflammatory bowel disease, and rheumatoid arthritis, highlighting its protective role in chronic inflammation. IL1F10 also contributes to limiting immune hyperactivation during infections and autoimmune responses. Knockdown or reduced expression of IL1F10 exacerbates inflammatory responses, increases cytokine production, and worsens tissue pathology, emphasizing its function as a key anti-inflammatory cytokine and immune homeostasis regulator.

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