IL1F10 antibody
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Name
IL1F10 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04236
Tested Applications
ELISA, WB
Description
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides(LPS). Ligand for IL-36R/IL1RL2.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | interleukin 1 family, member 10(theta) (IL1F10) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 9H1 |
| Observed MW | 17 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8WWZ1 |
| Gene ID | 84639 |
| Alias | IL-38,IL-1F10,IL1F10,IL38 |
| Background | Antibody anti-IL1F10 |
| Status | RUO |
| Note | Mol. Weight 17 kDa |
Background
IL1F10, also known as IL-38, is a member of the IL-1 cytokine family that plays an emerging role in immune modulation and inflammation control. IL1F10 binds to the IL-36 receptor (IL1RL2) and acts as an anti-inflammatory cytokine by antagonizing IL-36 signaling pathways. It inhibits the activation of NF-κB and MAPK, thereby suppressing the production of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-17. IL1F10 is expressed in immune cells, epithelial cells, and barrier tissues, including the skin, lungs, and gastrointestinal tract, where it regulates inflammation and maintains tissue homeostasis. It has been shown to counteract the effects of IL-36 agonists in diseases like psoriasis, inflammatory bowel disease, and rheumatoid arthritis, highlighting its protective role in chronic inflammation. IL1F10 also contributes to limiting immune hyperactivation during infections and autoimmune responses. Knockdown or reduced expression of IL1F10 exacerbates inflammatory responses, increases cytokine production, and worsens tissue pathology, emphasizing its function as a key anti-inflammatory cytokine and immune homeostasis regulator.
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