IL36A antibody
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935106861
info@markelab.com
name
IL36A antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04239
tested applications
ELISA, WB, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 1 family, member 6(epsilon) (IL36A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UHA7 |
| Alias | IL1F6, IL-36α, IL36α,IL-36 alpha,IL36 alpha,IL-36a,IL36a, IL36A, IL-36A,IL-1F6 |
| Background | Antibody anti-IL36A |
| Status | RUO |
| Note | This product is for research use only. |
IL36A, a member of the IL-1 family, is a pro-inflammatory cytokine that signals through the IL36 receptor (IL1RL2) and IL1RAP to activate downstream NF-κB, JNK, and MAPK pathways. IL36A is primarily expressed in epithelial cells, keratinocytes, and immune cells, where it plays a pivotal role in skin and mucosal immunity. It drives the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides, enhancing immune cell recruitment and tissue defense against infections and injury. IL36A is essential in amplifying innate and adaptive immune responses, particularly in barrier tissues such as the skin, lungs, and gastrointestinal tract. Dysregulation of IL36A is strongly associated with inflammatory skin disorders, including psoriasis, where excessive IL36 signaling exacerbates inflammation and keratinocyte proliferation. It is also implicated in inflammatory bowel disease and rheumatoid arthritis. Knockout studies reveal reduced inflammatory responses, impaired epithelial immunity, and defective immune cell recruitment, emphasizing IL36A’s critical role in tissue-specific immunity, inflammation amplification, and barrier function maintenance.
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