Mouse Interleukin-36 Receptor Antagonist Protein (IL36RN) ELISA Kit
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935106861
info@markelab.com
Precio
546€ (96 tests)
Elisa kits for IL36RN
proveedor
Abbexareference
abx254077Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Interleukin-36 Receptor Antagonist Protein (IL36RN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Interleukin 1 Delta concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Background
IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.
Características del producto
category
ELISA Kits
immunogen target
Interleukin-36 Receptor Antagonist Protein (IL36RN)
reactivity
Mouse
test range
31.2 pg/ml - 2000 pg/ml
sensitivity
18.8 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
IL36RN
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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