Human IL36A (Interleukin-36 alpha) ELISA Kit

Product specifications

ELISA Kits

Human

Colorimetric

4 hours

Sandwich ELISA, Double Antibody

0.156-10ng/ml

0.094ng/ml

96T

ELISA

Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples

Shipped within 10-14 working days.

2-8 °C for 12 months

Q9UHA7

IL1F6, IL-36α, IL36α,IL-36 alpha,IL36 alpha,IL-36a,IL36a, IL36A, IL-36A,IL-1F6

Elisa kits for IL36A

RUO

IL36A, a member of the IL-1 family, is a pro-inflammatory cytokine that signals through the IL36 receptor (IL1RL2) and IL1RAP to activate downstream NF-κB, JNK, and MAPK pathways. IL36A is primarily expressed in epithelial cells, keratinocytes, and immune cells, where it plays a pivotal role in skin and mucosal immunity. It drives the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides, enhancing immune cell recruitment and tissue defense against infections and injury. IL36A is essential in amplifying innate and adaptive immune responses, particularly in barrier tissues such as the skin, lungs, and gastrointestinal tract. Dysregulation of IL36A is strongly associated with inflammatory skin disorders, including psoriasis, where excessive IL36 signaling exacerbates inflammation and keratinocyte proliferation. It is also implicated in inflammatory bowel disease and rheumatoid arthritis. Knockout studies reveal reduced inflammatory responses, impaired epithelial immunity, and defective immune cell recruitment, emphasizing IL36A’s critical role in tissue-specific immunity, inflammation amplification, and barrier function maintenance.

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