Human Interleukin 37 (IL37) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein IL37
proveedor
Abbexareference
abx067422Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Interleukin 1 Zeta (IL1z) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
IL37 is a unique member of the IL-1 family that functions as an anti-inflammatory cytokine by suppressing immune activation and limiting excessive inflammation. IL37 is synthesized as a precursor that translocates to the nucleus or binds to the IL-18 receptor alpha chain (IL18Rα) and IL1R8 (SIGIRR), leading to inhibition of NF-κB, MAPK, and inflammatory cytokine production. It is expressed in epithelial cells, monocytes, and dendritic cells, particularly during inflammatory and infectious conditions. IL37 acts as a master suppressor of inflammation by reducing pro-inflammatory cytokine levels, chemokine production, and immune cell activation. It plays a protective role in autoimmune diseases, cardiovascular diseases, and metabolic disorders, where its overexpression reduces inflammation and tissue damage. Dysregulation of IL37 is linked to chronic inflammatory diseases such as rheumatoid arthritis, lupus, and colitis. Knockdown studies demonstrate exacerbated inflammation, increased cytokine production, and tissue pathology, highlighting IL37's role as a crucial anti-inflammatory mediator and immune regulator in maintaining tissue homeostasis and controlling immune responses.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 37 (IL37)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 22.0 kDa Observed MW (SDS-PAGE): 22 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys27-Asp192 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL37
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL-37,IL37,IL-1F7, IL-1F7, IL-1H, IL-23
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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