Pre-IL18 antibody
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935106861
info@markelab.com
name
Pre-IL18 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06764
tested applications
ELISA, WB, IP, IHC, IF
Description
IL18, is a proinflammatory cytokine involved in the development of Th1 cells and in immune response. It can stimulate the NK cells and certain T cells to release interferon gamma which plays an important role in activating the macrophages or other cells. IL18 has been demonstrated to have the potential to enhance Fas ligand-mediated cytotoxicity, which is increased in PE and regulates placental apoptosis. IL18 is synthesized as a 24 kDa precursor and then cleaved into a biologically activate 18 kDa form. This antibody is raised against the full length IL18 precursor, and it recognizes both the pre-IL18 and mature IL18 theoretically.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 18(interferon-gamma-inducing factor) (Pre-IL18) |
| Host | Rabbit |
| Reactivity | Human, RAT |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:500-1:5000 ; IHC: 1:50-1:500; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 24 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14116 |
| Alias | IL18,IL-18, IGIF, IL1F4,IL-1F4 |
| Background | Antibody anti-IL18 |
| Status | RUO |
| Note | Mol. Weight 24 kDa |
Descripción
IL18 is a pro-inflammatory cytokine and a member of the interleukin-1 (IL-1) family, playing a critical role in innate and adaptive immunity. IL18 is produced as an inactive precursor (pro-IL18) and activated by caspase-1 following inflammasome activation. It signals through the IL18 receptor complex, comprising IL18R1 and IL18RAP, leading to the activation of NF-κB, MAPK, and JNK pathways, which promote IFN-γ production, cytokine release, and immune cell activation. IL18 is primarily produced by macrophages, dendritic cells, and epithelial cells in response to infections, tissue damage, and inflammatory stimuli. It plays a pivotal role in enhancing Th1 immune responses, promoting NK cell activation, and inducing IFN-γ-dependent pathogen clearance. Additionally, IL18 supports Th2 and Th17 responses under specific conditions, contributing to allergic inflammation and autoimmunity. Dysregulation of IL18 is associated with chronic inflammation, autoimmune diseases (e.g., rheumatoid arthritis, lupus), and tumor progression, where excessive IL18 signaling exacerbates tissue damage and immune imbalance. Knockout studies show impaired IFN-γ production, defective NK and Th1 responses, and increased susceptibility to infections, underscoring IL18's essential role in immune regulation and host defense.
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