Interleukin-36 Receptor Antagonist Protein (IL36RN) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Interleukin-36 Receptor Antagonist Protein (IL36RN) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005733
tested applications
WB
Description
IL36RN Antibody is a Rabbit Polyclonal Antibody against IL36RN.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin-36 Receptor Antagonist Protein (IL36RN) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBH0 |
| Gene ID | 26525 |
| NCBI Accession | NP_036407.1 |
| Alias | IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5 |
| Background | Antibody anti-IL36RN |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.
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