Human Interleukin 36 Gamma / IL1F9 (IL36G) Protein

Este producto es parte de IL36G - Interleukin-36 gamma
Human Interleukin 36 Gamma / IL1F9 (IL36G) Protein

Pida mas información

935106861

info@markelab.com

Precio

767€ (50 µg)

Protein IL36G

proveedor

Abbexa

reference

abx651365

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Interleukin 1 Family, Member 9 (IL1F9) Protein (Active) is an active protein from Human.


Background

IL36G, another member of the IL-1 family, functions as a potent pro-inflammatory cytokine by signaling through the IL-36 receptor (IL1RL2) and IL1RAP, leading to activation of NF-κB, ERK, and MAPK pathways. IL36G is highly expressed in epithelial cells, particularly in the skin, lungs, and gastrointestinal tract, where it acts as an amplifier of local inflammation. It induces the production of cytokines, chemokines, and antimicrobial peptides, enhancing the recruitment of immune cells like T cells, dendritic cells, and neutrophils to barrier tissues during infection, injury, or inflammatory insults. IL36G plays a critical role in psoriasis pathogenesis, where it triggers keratinocyte proliferation and immune cell infiltration, contributing to chronic inflammation and skin remodeling. Dysregulated IL36G expression is also associated with respiratory diseases and inflammatory bowel disease. Knockdown studies show impaired immune cell recruitment and weakened epithelial responses, highlighting IL36G's role as an inflammation driver, immune amplifier, and barrier tissue regulator.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Interleukin 36 Gamma / IL1F9 (IL36G)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 19.1 kDa Observed MW: 19 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ala162 Tag: N-terminal His tag


purity

> 90%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL36G


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL1F9, IL-36γ, IL36γ,IL-36 gamma,IL36 gamma,IL-36g,IL36g,IL36G,IL-36G,IL-1F9


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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