Human IL36G(Interleukin-36 gamma) ELISA Kit

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935106861
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Precio
Precio a consultar
Elisa Kits IL36G
proveedor
FineTestreference
EH0628Tested Applications
reactivity
humanstatus
RUOclonality
Background
IL36G, another member of the IL-1 family, functions as a potent pro-inflammatory cytokine by signaling through the IL-36 receptor (IL1RL2) and IL1RAP, leading to activation of NF-κB, ERK, and MAPK pathways. IL36G is highly expressed in epithelial cells, particularly in the skin, lungs, and gastrointestinal tract, where it acts as an amplifier of local inflammation. It induces the production of cytokines, chemokines, and antimicrobial peptides, enhancing the recruitment of immune cells like T cells, dendritic cells, and neutrophils to barrier tissues during infection, injury, or inflammatory insults. IL36G plays a critical role in psoriasis pathogenesis, where it triggers keratinocyte proliferation and immune cell infiltration, contributing to chronic inflammation and skin remodeling. Dysregulated IL36G expression is also associated with respiratory diseases and inflammatory bowel disease. Knockdown studies show impaired immune cell recruitment and weakened epithelial responses, highlighting IL36G's role as an inflammation driver, immune amplifier, and barrier tissue regulator.
Características del producto
category
ELISA Kits
reactivity
human
test range
31.25-2000pg/ml
assay type
Sandwich ELISA, Double Antibody
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,Other biological fluids
size 1
96T
alias
IL1F9, IL-36γ, IL36γ,IL-36 gamma,IL36 gamma,IL-36g,IL36g,IL36G,IL-36G,IL-1F9
storage
2-8 °C for 6 months
or code
IL36G
uniprot id
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