Human Interleukin 36 Gamma / IL1F9 (IL36G) Protein

Pida mas información
935106861
info@markelab.com
Precio
234€ (10 µg)
Protein IL36G
proveedor
Abbexareference
abx067397Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Interleukin 1 Family, Member 9 (IL1F9) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
IL36G, another member of the IL-1 family, functions as a potent pro-inflammatory cytokine by signaling through the IL-36 receptor (IL1RL2) and IL1RAP, leading to activation of NF-κB, ERK, and MAPK pathways. IL36G is highly expressed in epithelial cells, particularly in the skin, lungs, and gastrointestinal tract, where it acts as an amplifier of local inflammation. It induces the production of cytokines, chemokines, and antimicrobial peptides, enhancing the recruitment of immune cells like T cells, dendritic cells, and neutrophils to barrier tissues during infection, injury, or inflammatory insults. IL36G plays a critical role in psoriasis pathogenesis, where it triggers keratinocyte proliferation and immune cell infiltration, contributing to chronic inflammation and skin remodeling. Dysregulated IL36G expression is also associated with respiratory diseases and inflammatory bowel disease. Knockdown studies show impaired immune cell recruitment and weakened epithelial responses, highlighting IL36G's role as an inflammation driver, immune amplifier, and barrier tissue regulator.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 36 Gamma / IL1F9 (IL36G)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 19.4 kDa Observed MW: 19 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ala162 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL36G
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL1F9, IL-36γ, IL36γ,IL-36 gamma,IL36 gamma,IL-36g,IL36g,IL36G,IL-36G,IL-1F9
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Human IL36G(Interleukin-36 gamma) ELISA Kit

proveedor
FineTestreference
EH0628reactivity
humanstatus
RUOPrecio a consultar
Ver másMouse IL36G(Interleukin-36 gamma) ELISA Kit

proveedor
FineTestreference
EM1873reactivity
mousestatus
RUOPrecio a consultar
Ver másanti- IL-36γ / IL-1F9 antibody

proveedor
FineTestreference
FNab04274Tested Applications
ELISA, WB, IHCreactivity
humanstatus
RUOclonality
polyclonalPrecio a consultar
Ver más