Interleukin 37 (IL37) Antibody (Biotin)

Pida mas información
935106861
info@markelab.com
Precio
299€ (200 µl)
Antibody anti-IL37
proveedor
Abbexareference
abx272365Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Interleukin 1 Zeta (IL1z) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Interleukin 1 Zeta (IL1z).
Background
IL37 is a unique member of the IL-1 family that functions as an anti-inflammatory cytokine by suppressing immune activation and limiting excessive inflammation. IL37 is synthesized as a precursor that translocates to the nucleus or binds to the IL-18 receptor alpha chain (IL18Rα) and IL1R8 (SIGIRR), leading to inhibition of NF-κB, MAPK, and inflammatory cytokine production. It is expressed in epithelial cells, monocytes, and dendritic cells, particularly during inflammatory and infectious conditions. IL37 acts as a master suppressor of inflammation by reducing pro-inflammatory cytokine levels, chemokine production, and immune cell activation. It plays a protective role in autoimmune diseases, cardiovascular diseases, and metabolic disorders, where its overexpression reduces inflammation and tissue damage. Dysregulation of IL37 is linked to chronic inflammatory diseases such as rheumatoid arthritis, lupus, and colitis. Knockdown studies demonstrate exacerbated inflammation, increased cytokine production, and tissue pathology, highlighting IL37's role as a crucial anti-inflammatory mediator and immune regulator in maintaining tissue homeostasis and controlling immune responses.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Interleukin 37 (IL37)
host
Rabbit
isotype
IgG
conjugation
Biotin
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by antigen-specific affinity chromatography.
recommended dilution
WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
200 µl
size 2
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
IL37
dry ice
No
availability
Shipped within 5-15 working days.
alias
IL-37,IL37,IL-1F7, IL-1F7, IL-1H, IL-23
Quizá le pueda interesar
Human IL37(Interleukin-37) ELISA Kit

proveedor
FineTestreference
EH1120reactivity
humanstatus
RUOPrecio a consultar
Ver másanti- IL37 antibody

proveedor
FineTestreference
FNab04275Tested Applications
ELISA, WB, IHCreactivity
humanstatus
RUOclonality
polyclonalSuppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function require...
Precio a consultar
Ver másanti- IL37 antibody

proveedor
FineTestreference
FNab04276Tested Applications
ELISA, WB,IHCreactivity
humanstatus
RUOclonality
monoclonalSuppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function require...
Precio a consultar
Ver más