Dog Interleukin 18 (IL18) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Dog Interleukin 18 (IL18) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx490894
tested applications
CLIA
Description
Dog Interleukin 18 (IL18) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 18 (IL18) |
| Reactivity | Dog |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | < 5.6 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL18,IL-18, IGIF, IL1F4,IL-1F4 |
| Background | CLIA Kits IL18 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL18 is a pro-inflammatory cytokine and a member of the interleukin-1 (IL-1) family, playing a critical role in innate and adaptive immunity. IL18 is produced as an inactive precursor (pro-IL18) and activated by caspase-1 following inflammasome activation. It signals through the IL18 receptor complex, comprising IL18R1 and IL18RAP, leading to the activation of NF-κB, MAPK, and JNK pathways, which promote IFN-γ production, cytokine release, and immune cell activation. IL18 is primarily produced by macrophages, dendritic cells, and epithelial cells in response to infections, tissue damage, and inflammatory stimuli. It plays a pivotal role in enhancing Th1 immune responses, promoting NK cell activation, and inducing IFN-γ-dependent pathogen clearance. Additionally, IL18 supports Th2 and Th17 responses under specific conditions, contributing to allergic inflammation and autoimmunity. Dysregulation of IL18 is associated with chronic inflammation, autoimmune diseases (e.g., rheumatoid arthritis, lupus), and tumor progression, where excessive IL18 signaling exacerbates tissue damage and immune imbalance. Knockout studies show impaired IFN-γ production, defective NK and Th1 responses, and increased susceptibility to infections, underscoring IL18's essential role in immune regulation and host defense.
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