Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit

Este producto es parte de IL1RN - Interleukin 1 Receptor Antagonist
Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

546€ (96 tests)

Elisa kits for IL1RN

proveedor

Abbexa

reference

abx050093

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin 1 Receptor Antagonist (IL1RN) concentrations in serum, plasma and other biological fluids.


Background

IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression

Características del producto

category

ELISA Kits


immunogen target

Interleukin 1 Receptor Antagonist (IL1RN)


reactivity

Human


test range

31.2 pg/ml - 2000 pg/ml


sensitivity

18.8 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Serum, plasma and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

IL1RN


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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