Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
546€ (96 tests)
Elisa kits for IL1RN
proveedor
Abbexareference
abx050093Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin 1 Receptor Antagonist (IL1RN) concentrations in serum, plasma and other biological fluids.
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
Características del producto
category
ELISA Kits
immunogen target
Interleukin 1 Receptor Antagonist (IL1RN)
reactivity
Human
test range
31.2 pg/ml - 2000 pg/ml
sensitivity
18.8 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
IL1RN
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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