IL-1 beta Protein
611€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
IL-1 beta Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx060294
tested applications
ELISA, SDS-PAGE
Description
IL-1 beta Protein is a Recombinant protein from Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL-1 beta |
| Host | E. coli |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, SDS-PAGE |
| Buffer | 10 mM Tris-HCl, pH 7.4±0.2. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01584 |
| Gene ID | 3553 |
| OMIM | 147720 |
| Alias | IL-1F2, IL-1β, IL1β,IL-1 beta,IL1 beta,IL-1b,IL1b,IL1B |
| Background | Protein IL1B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL1B is a major pro-inflammatory cytokine that belongs to the IL-1 family and plays a central role in inflammation, fever induction, and host defense. It is synthesized as an inactive precursor (pro-IL1B) in response to pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and is cleaved into its active form by caspase-1 through inflammasome activation. IL1B binds to its receptor IL1R1, forming a signaling complex with IL1RAP, which activates downstream NF-κB, MAPK, and JNK pathways to drive the expression of cytokines, chemokines, and acute-phase proteins. IL1B is predominantly produced by activated monocytes, macrophages, and dendritic cells during infections, tissue damage, or inflammatory conditions. It plays a critical role in immune cell recruitment, pathogen clearance, and tissue repair, but excessive IL1B signaling leads to chronic inflammation, autoimmune disorders, and tumor progression. Dysregulation of IL1B is implicated in diseases such as rheumatoid arthritis, gout, and neuroinflammation. Knockout studies demonstrate impaired inflammatory responses, reduced cytokine production, and weakened host defense, highlighting IL1B's essential role in immune activation, inflammation, and disease pathogenesis.
Related Products
Bovine IL-1b (Interleukin 1 Beta) ELISA Kit
Ver Producto
Canine IL-1β (Interleukin 1 Beta) ELISA Kit
Ver Producto