Human IL36B (Interleukin-36 beta) ELISA Kit

Este producto es parte de IL36B - Interleukin-36 beta
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935106861
info@markelab.com
name
Human IL36B (Interleukin-36 beta) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH2046
tested applications
ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Human
Detection Method
Colorimetric
Assay Data
4 hours
Assay Type
Sandwich ELISA, Double Antibody
Test Range
31.25-2000pg/ml
Sensitivity
18.75pg/ml
Size 1
96T
Tested Applications
ELISA
Sample Type
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Availability
Shipped within 10-14 working days.
Storage
2-8 °C for 12 months
UniProt ID
Q9NZH7
Alias
IL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8
Background
Elisa kits for IL36B
Status
RUO

IL36B is a pro-inflammatory cytokine of the IL-1 family that functions by signaling through the IL-36 receptor (IL1RL2) and its co-receptor IL1RAP. IL36B activates downstream NF-κB, MAPK, and JNK pathways, inducing the expression of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. It is primarily expressed in epithelial cells, particularly in skin keratinocytes, and serves a key role in enhancing immune responses at epithelial barriers. IL36B promotes the recruitment and activation of immune cells such as dendritic cells, neutrophils, and T cells, amplifying inflammation in tissues exposed to pathogens or injury. It is a major driver of inflammatory processes in skin disorders, including psoriasis, where its overexpression leads to keratinocyte hyperproliferation and immune cell infiltration. IL36B is also involved in mucosal immunity within the lungs and gastrointestinal tract. Knockdown studies reveal impaired epithelial immunity, reduced inflammatory responses, and delayed wound healing, underscoring its role in amplifying innate immune responses, tissue defense, and inflammation regulation.

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