Human Interleukin 36 Alpha (IL36A) Protein
234€ (10 µg)
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935106861
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name
Human Interleukin 36 Alpha (IL36A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168251
tested applications
WB, SDS-PAGE
Description
Human Interleukin 1 Epsilon Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 36 Alpha (IL36A) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 21.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Phe158 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UHA7 |
| Alias | IL1F6, IL-36α, IL36α,IL-36 alpha,IL36 alpha,IL-36a,IL36a, IL36A, IL-36A,IL-1F6 |
| Background | Protein IL36A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL36A, a member of the IL-1 family, is a pro-inflammatory cytokine that signals through the IL36 receptor (IL1RL2) and IL1RAP to activate downstream NF-κB, JNK, and MAPK pathways. IL36A is primarily expressed in epithelial cells, keratinocytes, and immune cells, where it plays a pivotal role in skin and mucosal immunity. It drives the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides, enhancing immune cell recruitment and tissue defense against infections and injury. IL36A is essential in amplifying innate and adaptive immune responses, particularly in barrier tissues such as the skin, lungs, and gastrointestinal tract. Dysregulation of IL36A is strongly associated with inflammatory skin disorders, including psoriasis, where excessive IL36 signaling exacerbates inflammation and keratinocyte proliferation. It is also implicated in inflammatory bowel disease and rheumatoid arthritis. Knockout studies reveal reduced inflammatory responses, impaired epithelial immunity, and defective immune cell recruitment, emphasizing IL36A’s critical role in tissue-specific immunity, inflammation amplification, and barrier function maintenance.
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