Human Interleukin-1 Family Member 10 (IL1F10) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Human Interleukin-1 Family Member 10 (IL1F10) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168252
tested applications
WB, SDS-PAGE
Description
Interleukin 1 Theta Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin-1 Family Member 10 (IL1F10) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 18.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala15-Trp152 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WWZ1 |
| Alias | IL-38,IL-1F10,IL1F10,IL38 |
| Background | Protein IL1F10 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL1F10, also known as IL-38, is a member of the IL-1 cytokine family that plays an emerging role in immune modulation and inflammation control. IL1F10 binds to the IL-36 receptor (IL1RL2) and acts as an anti-inflammatory cytokine by antagonizing IL-36 signaling pathways. It inhibits the activation of NF-κB and MAPK, thereby suppressing the production of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-17. IL1F10 is expressed in immune cells, epithelial cells, and barrier tissues, including the skin, lungs, and gastrointestinal tract, where it regulates inflammation and maintains tissue homeostasis. It has been shown to counteract the effects of IL-36 agonists in diseases like psoriasis, inflammatory bowel disease, and rheumatoid arthritis, highlighting its protective role in chronic inflammation. IL1F10 also contributes to limiting immune hyperactivation during infections and autoimmune responses. Knockdown or reduced expression of IL1F10 exacerbates inflammatory responses, increases cytokine production, and worsens tissue pathology, emphasizing its function as a key anti-inflammatory cytokine and immune homeostasis regulator.
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