Human Interleukin 36 Beta (IL36B) ELISA Kit
643.5€ (96 tests)
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name
Human Interleukin 36 Beta (IL36B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx152010
tested applications
ELISA
Description
Human Interleukin 36 Beta (IL36B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin 36 Beta (IL36B) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Interleukin 1 Eta (IL1h)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Interleukin 36 Beta (IL36B) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 7.8 pg/ml - 500 pg/ml |
| Sensitivity | < 2.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8 |
| Background | Elisa kits for IL36B |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL36B is a pro-inflammatory cytokine of the IL-1 family that functions by signaling through the IL-36 receptor (IL1RL2) and its co-receptor IL1RAP. IL36B activates downstream NF-κB, MAPK, and JNK pathways, inducing the expression of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. It is primarily expressed in epithelial cells, particularly in skin keratinocytes, and serves a key role in enhancing immune responses at epithelial barriers. IL36B promotes the recruitment and activation of immune cells such as dendritic cells, neutrophils, and T cells, amplifying inflammation in tissues exposed to pathogens or injury. It is a major driver of inflammatory processes in skin disorders, including psoriasis, where its overexpression leads to keratinocyte hyperproliferation and immune cell infiltration. IL36B is also involved in mucosal immunity within the lungs and gastrointestinal tract. Knockdown studies reveal impaired epithelial immunity, reduced inflammatory responses, and delayed wound healing, underscoring its role in amplifying innate immune responses, tissue defense, and inflammation regulation.
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