Interleukin-36 Receptor Antagonist Protein (IL36RN) Antibody
169€ (20 µl)
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Name
Interleukin-36 Receptor Antagonist Protein (IL36RN) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320513
Tested Applications
ELISA, IHC
Description
IL36RN Antibody is a Rabbit Polyclonal against IL36RN.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin-36 Receptor Antagonist Protein (IL36RN) Immunogen: Recombinant human Interleukin-36 receptor antagonist protein (1-155AA). |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.44 mg/ml |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBH0 |
| Gene ID | 26525 |
| OMIM | 605507 |
| Alias | IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5 |
| Background | Antibody anti-IL36RN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.
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