Human Interleukin 36 Alpha (IL36A) CLIA Kit
845€ (96 tests)
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name
Human Interleukin 36 Alpha (IL36A) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx190210
tested applications
CLIA
Description
Human Interleukin 1 Epsilon (IL1e) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 36 Alpha (IL36A) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 1.37 pg/ml - 1000 pg/ml |
| Sensitivity | < 0.64 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL1F6, IL-36α, IL36α,IL-36 alpha,IL36 alpha,IL-36a,IL36a, IL36A, IL-36A,IL-1F6 |
| Background | CLIA Kits IL36A |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL36A, a member of the IL-1 family, is a pro-inflammatory cytokine that signals through the IL36 receptor (IL1RL2) and IL1RAP to activate downstream NF-κB, JNK, and MAPK pathways. IL36A is primarily expressed in epithelial cells, keratinocytes, and immune cells, where it plays a pivotal role in skin and mucosal immunity. It drives the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides, enhancing immune cell recruitment and tissue defense against infections and injury. IL36A is essential in amplifying innate and adaptive immune responses, particularly in barrier tissues such as the skin, lungs, and gastrointestinal tract. Dysregulation of IL36A is strongly associated with inflammatory skin disorders, including psoriasis, where excessive IL36 signaling exacerbates inflammation and keratinocyte proliferation. It is also implicated in inflammatory bowel disease and rheumatoid arthritis. Knockout studies reveal reduced inflammatory responses, impaired epithelial immunity, and defective immune cell recruitment, emphasizing IL36A’s critical role in tissue-specific immunity, inflammation amplification, and barrier function maintenance.
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