Interleukin 36 Beta (IL36B) Antibody
351€ (100 µg)
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935106861
info@markelab.com
name
Interleukin 36 Beta (IL36B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375269
tested applications
ELISA, WB, IHC
Description
Interleukin-1 Family Member 8 (IL1F8) Antibody is a Rabbit Polyclonal antibody against Interleukin 36 Beta (IL36B).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 36 Beta (IL36B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZH7 |
| Gene ID | 27177 |
| Alias | IL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8 |
| Background | Antibody anti-IL36B |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
IL36B is a pro-inflammatory cytokine of the IL-1 family that functions by signaling through the IL-36 receptor (IL1RL2) and its co-receptor IL1RAP. IL36B activates downstream NF-κB, MAPK, and JNK pathways, inducing the expression of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. It is primarily expressed in epithelial cells, particularly in skin keratinocytes, and serves a key role in enhancing immune responses at epithelial barriers. IL36B promotes the recruitment and activation of immune cells such as dendritic cells, neutrophils, and T cells, amplifying inflammation in tissues exposed to pathogens or injury. It is a major driver of inflammatory processes in skin disorders, including psoriasis, where its overexpression leads to keratinocyte hyperproliferation and immune cell infiltration. IL36B is also involved in mucosal immunity within the lungs and gastrointestinal tract. Knockdown studies reveal impaired epithelial immunity, reduced inflammatory responses, and delayed wound healing, underscoring its role in amplifying innate immune responses, tissue defense, and inflammation regulation.
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