Interleukin 1 Receptor Antagonist (IL1RN) Antibody Pair
Pida mas información
935106861
info@markelab.com
Precio
1170€ (5 × 96 tests)
Antibody Pair for IL1RN
proveedor
Abbexareference
abx370827Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Interleukin 1 Receptor Antagonist (IL1RN) Antibody Pair for use in Sandwich ELISA assay development.
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
Características del producto
category
Antibody Pairs
reactivity
Human
immunogen target
Interleukin 1 Receptor Antagonist (IL1RN)
form
Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user.
tested applications
ELISA
size 1
5 × 96 tests
size 2
10 × 96 tests
recommended dilution
Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user.
buffer
The Capture and Detection Antibody both contain 0.1% sodium azide.
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
IL1RN
dry ice
No
availability
Shipped within 5-20 working days.
alias
IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor
uniprot id
note
This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only.
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