Interleukin 1 Receptor Antagonist (IL1RN) Antibody Pair
1170€ (5 × 96 tests)
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Name
Interleukin 1 Receptor Antagonist (IL1RN) Antibody Pair
Category
Antibody Pairs
Provider
Abbexa
Reference
abx370827
Tested Applications
ELISA
Description
Interleukin 1 Receptor Antagonist (IL1RN) Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains: Detection: 50 µg Capture: 200 µg Standard: 2 µg
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Antibody Pairs |
| Immunogen Target | Interleukin 1 Receptor Antagonist (IL1RN) |
| Reactivity | Human |
| Assay Data | Concentration Capture Antibody: 0.5 mg/ml Concentration Biotin-Conjugated Detection Antibody: 0.2 mg/ml Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
| Assay Type | Sandwich |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Biotin |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard form: Lyophilized Capture Ab: Liquid Detection Ab: Liquid |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Shipped within 5-20 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P18510 |
| Gene ID | 3557 |
| OMIM | 147679 |
| Alias | IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor |
| Background | Antibody pair for IL1RN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
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