Human Interleukin 1 Receptor Antagonist (IL1RN) Protein
Pida mas información
935106861
info@markelab.com
Precio
195€ (10 µg)
Protein IL1RN
proveedor
Abbexareference
abx067402Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Interleukin 1 Receptor Antagonist (IL1RN) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 1 Receptor Antagonist (IL1RN)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 18.4 kDa Observed MW (SDS-PAGE): 18 kDa Concentration: Prior to lyophilization: 20 µg/ml Sequence Fragment: Arg26-Glu177 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL1RN
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Bovine IL1ra(Interleukin 1 Receptor Antagonist) ELISA Kit
proveedor
FineTestreference
EB0169reactivity
bovinestatus
RUOPrecio a consultar
Ver másHuman IL-1ra/IL-1F3(Interleukin 1 Receptor Antagonist) ELISA Kit
proveedor
FineTestreference
EH0172reactivity
humanstatus
RUOPrecio a consultar
Ver másMouse IL-1ra(Interleukin 1 Receptor Antagonist) ELISA Kit
proveedor
FineTestreference
EM1904reactivity
mousestatus
RUOPrecio a consultar
Ver más