Mouse Interleukin 1 Receptor Antagonist (IL1RN) Protein

Este producto es parte de IL1RN - Interleukin 1 Receptor Antagonist
Mouse Interleukin 1 Receptor Antagonist (IL1RN) Protein

Pida mas información

935106861

info@markelab.com

Precio

715€ (50 µg)

Protein IL1RN

proveedor

Abbexa

reference

abx651367

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Interleukin 1 Receptor Antagonist (IL1RN) Protein (Active) is an active protein from Mouse.


Background

IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Interleukin 1 Receptor Antagonist (IL1RN)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 18.4 kDa Observed MW: 20 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg27-Gln178 Tag: N-terminal His tag


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL1RN


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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