Guinea pig Interleukin 1 Alpha (IL1a) Protein

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935106861
info@markelab.com
Precio
468€ (50 µg)
Protein IL1A
proveedor
Abbexareference
abx067383Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Interleukin 1 Alpha (IL1a) is a recombinant Guinea pig protein produced in a Prokaryotic expression system (E. coli).
Background
IL1A is a pro-inflammatory cytokine and a member of the interleukin-1 (IL-1) family, acting as a potent mediator of inflammation, immune responses, and tissue homeostasis. IL1A is produced as a precursor protein that can function in its membrane-bound or cleaved active form following cellular stress, necrosis, or damage. It signals through the interleukin-1 receptor (IL1R1) and its co-receptor IL1RAP, activating downstream NF-κB, AP-1, and MAPK pathways, which drive the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules. IL1A is primarily expressed by epithelial cells, keratinocytes, monocytes, and macrophages in response to infections, tissue injury, or inflammatory stimuli. It plays critical roles in host defense, fever induction, and leukocyte recruitment while also modulating tissue repair and homeostasis. Dysregulated IL1A activity contributes to chronic inflammatory diseases, cancer progression, and fibrosis. Knockout studies reveal impaired inflammatory responses, reduced leukocyte recruitment, and delayed tissue repair, highlighting IL1A's role in initiating inflammation, immune signaling, and maintaining tissue integrity.
Características del producto
category
Proteins and Peptides
origin
Guinea pig
host
E. coli
immunogen target
Interleukin 1 Alpha (IL1a)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 16.5 kDa Observed MW (SDS-PAGE): 16/18 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser111-Glu204 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL1A
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL-1F1, IL-1α, IL1α,IL-1 alpha,IL1 alpha,IL-1a,IL1a,IL1A
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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