Guinea pig Interleukin 1 Alpha (IL1a) Protein

Este producto es parte de IL1A - Interleukin-1 alpha
Guinea pig Interleukin 1 Alpha (IL1a) Protein

Pida mas información

935106861

info@markelab.com

Precio

468€ (50 µg)

Protein IL1A

proveedor

Abbexa

reference

abx067383

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Interleukin 1 Alpha (IL1a) is a recombinant Guinea pig protein produced in a Prokaryotic expression system (E. coli).


Background

IL1A is a pro-inflammatory cytokine and a member of the interleukin-1 (IL-1) family, acting as a potent mediator of inflammation, immune responses, and tissue homeostasis. IL1A is produced as a precursor protein that can function in its membrane-bound or cleaved active form following cellular stress, necrosis, or damage. It signals through the interleukin-1 receptor (IL1R1) and its co-receptor IL1RAP, activating downstream NF-κB, AP-1, and MAPK pathways, which drive the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules. IL1A is primarily expressed by epithelial cells, keratinocytes, monocytes, and macrophages in response to infections, tissue injury, or inflammatory stimuli. It plays critical roles in host defense, fever induction, and leukocyte recruitment while also modulating tissue repair and homeostasis. Dysregulated IL1A activity contributes to chronic inflammatory diseases, cancer progression, and fibrosis. Knockout studies reveal impaired inflammatory responses, reduced leukocyte recruitment, and delayed tissue repair, highlighting IL1A's role in initiating inflammation, immune signaling, and maintaining tissue integrity.

Características del producto

category

Proteins and Peptides


origin

Guinea pig


host

E. coli


immunogen target

Interleukin 1 Alpha (IL1a)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 16.5 kDa Observed MW (SDS-PAGE): 16/18 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser111-Glu204 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL1A


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL-1F1, IL-1α, IL1α,IL-1 alpha,IL1 alpha,IL-1a,IL1a,IL1A


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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