PLEKHA - Pleckstrin homology domain containing A1| Elisa - Clia - Antibody - Protein

Family main features

Bachground:

PLEKHA1 (Pleckstrin Homology Domain Containing A1) is a protein involved in intracellular signaling and cytoskeletal organization. The pleckstrin homology (PH) domain is a common protein domain involved in targeting proteins to cell membranes by binding to phosphoinositides. PLEKHA1 has been implicated in various cellular processes, including cell migration, survival, and signaling. It is expressed in many tissues, but its expression levels and functions can vary significantly depending on the cell type and physiological conditions. Research has shown that PLEKHA1 plays a role in disease mechanisms, particularly in cancer and diabetes, making it a potential therapeutic target.


Protein Structure

PLEKHA1 is characterized by the presence of a pleckstrin homology (PH) domain, which is essential for its function:

  • PH Domain: This domain facilitates the binding of PLEKHA1 to phosphoinositides in cell membranes, particularly phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2), which helps localize the protein to specific membrane sites.
  • C-terminal Region: Involved in protein-protein interactions, contributing to its role in signaling pathways and cytoskeletal organization.


Classification and Subtypes

PLEKHA1 is part of the Pleckstrin Homology Domain Containing (PLEKHA) family. This family consists of several proteins that share the PH domain and are involved in various signaling and cytoskeletal functions. Other members of the PLEKHA family include PLEKHA2, PLEKHA3, and PLEKHA4, each with distinct but sometimes overlapping functions.


Function and Biological Significance

PLEKHA1 is involved in several key cellular processes:

  • Signal Transduction: By binding to phosphoinositides, PLEKHA1 participates in the recruitment and activation of signaling proteins at the cell membrane, playing a role in pathways such as the PI3K/AKT pathway, which is crucial for cell growth and survival.
  • Cell Migration and Adhesion: PLEKHA1's interaction with the actin cytoskeleton and its localization to cell membranes influence cell motility and adhesion, processes that are critical in development, wound healing, and cancer metastasis.
  • Endocytosis and Vesicle Trafficking: It is implicated in the regulation of endocytosis and intracellular vesicle trafficking, which are essential for nutrient uptake, receptor recycling, and signal transduction.


Clinical Issues

Dysregulation or mutations in PLEKHA1 have been linked to several diseases:

  • Cancer: Altered expression of PLEKHA1 is observed in various cancers, including breast, prostate, and ovarian cancers, where it may contribute to tumor progression and metastasis by affecting cell migration and signaling pathways.
  • Diabetes: Studies have suggested that PLEKHA1 may play a role in insulin signaling and glucose metabolism, implicating it in the pathophysiology of diabetes.
  • Neurological Disorders: Given its role in cytoskeletal organization and signal transduction, PLEKHA1 may also be involved in neurodevelopmental and neurodegenerative disorders, although more research is needed in this area.


Summary

PLEKHA1 (Pleckstrin Homology Domain Containing A1) is a protein that plays a crucial role in intracellular signaling, cytoskeletal organization, and membrane dynamics. It is characterized by its PH domain, which binds to phosphoinositides, targeting the protein to specific cell membranes. PLEKHA1 is involved in critical cellular processes such as signal transduction, cell migration, adhesion, and vesicle trafficking. Dysregulation of PLEKHA1 has been linked to various diseases, including cancer, diabetes, and potentially neurological disorders, highlighting its importance in cellular function and its potential as a therapeutic target. Understanding the mechanisms of PLEKHA1 function and regulation provides valuable insights into its role in health and disease.

PLEKHA1 Recommended name:

Pleckstrin homology domain containing A1 (PLEKHA1)

Aliases for PLEKHA1

PLEKHA1, TAPP1, PH domain-containing family A member 1,Tandem PH domain-containing protein 1

PLEKHA2 Recommended name:

Pleckstrin homology domain containing A2 (PLEKHA2)

Aliases for PLEKHA2

TAPP2,PH domain-containing family A member 2,Tandem PH domain-containing protein 2

PLEKHA3 Recommended name:

Pleckstrin homology domain containing A3 (PLEKHA3)

Aliases for PLEKHA3

FAPP1,PH domain-containing family A member 3,Phosphatidylinositol-four-phosphate adapter protein 1 

PLEKHA4 Recommended name:

Pleckstrin homology domain containing A4 (PLEKHA4)

Aliases for PLEKHA4

PEPP1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1

PLEKHA5 Recommended name:

Pleckstrin homology domain containing A5 (PLEKHA5)

Aliases for PLEKHA5

PLEKHA5, KIAA1686, PEPP2,PH domain-containing family A member 5,Phosphoinositol 3-phosphate-binding protein 2

PLEKHA6 Recommended name:

Pleckstrin homology domain containing A6 (PLEKHA6)

Aliases for PLEKHA6

KIAA0969, PEPP3,PH domain-containing family A member 6,Phosphoinositol 3-phosphate-binding protein 3,PEPP-3

PLEKHA7 Recommended name:

Pleckstrin homology domain containing A7 (PLEKHA7)

Aliases for PLEKHA7

PH domain-containing family A member 7

PLEKHA8 Recommended name:

Pleckstrin homology domain containing A8 (PLEKHA8)

Aliases for PLEKHA8

FAPP2,PH domain-containing family A member 8,Phosphatidylinositol-four-phosphate adapter protein 2,FAPP-2

PLEKHA8P1 Recommended name:

Pleckstrin homology domain-containing A8 pseudogene 1 (PLEKHA8P1)

Aliases for PLEKHA8P1

PLEKHA8P1,PLEKHA9,FAPP2,FAPP-2,Hfapp2,PLEKHA8,Putative protein PLEKHA9

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con PLEKHA - Pleckstrin homology domain containing A1

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 55 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaPLEKHA1abx382284Human Pleckstrin Homology Domain Containing A1 (PLEKHA1) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich0.156 ng/ml - 10 ng/ml< 0.094 ng/ml687.596 testsQ9HB21RUO
AbbexaPLEKHA2abx539029Human Pleckstrin homology domain-containing family A member 2 (PLEKHA2) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ9HB19RUO
AbbexaPLEKHA3abx382285Human Pleckstrin Homology Domain Containing A3 (PLEKHA3) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich0.313 ng/ml - 20 ng/ml< 0.188 ng/ml687.596 testsQ9HB20RUO
AbbexaPLEKHA4abx539033Human Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ9H4M7RUO
AbbexaPLEKHA5abx382286Human Pleckstrin Homology Domain Containing A5 (PLEKHA5) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich0.156 ng/ml - 10 ng/ml< 0.094 ng/ml687.596 testsQ9HAU0RUO
AbbexaPLEKHA6abx539037Human Pleckstrin homology domain-containing family A member 6 (PLEKHA6) ELISA KitHumanSerum,Plasma,Tissue homogenates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ9Y2H5RUO
AbbexaPLEKHA7abx539039Human Pleckstrin homology domain-containing family A member 7 (PLEKHA7) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ6IQ23RUO
AbbexaPLEKHA8abx382287Human Pleckstrin Homology Domain Containing A8 (PLEKHA8) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich0.313 ng/ml - 20 ng/ml< 0.188 ng/ml687.596 testsQ96JA3RUO
AbbexaPLEKHA8P1abx382288Human Pleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9) ELISA KitHumanSerum,Plasma,Other biological fluidsSandwich0.156 ng/ml - 10 ng/ml< 0.094 ng/ml687.596 testsO95397RUO
AbbexaPLEKHA1abx539027Mouse Pleckstrin homology domain-containing family A member 1 (PLEKHA1) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ8BUL6RUO
AbbexaPLEKHA2abx539030Mouse Pleckstrin homology domain-containing family A member 2 (PLEKHA2) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ9ERS5RUO
AbbexaPLEKHA3abx539032Mouse Pleckstrin homology domain-containing family A member 3 (PLEKHA3) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ9ERS4RUO
AbbexaPLEKHA4abx539034Mouse Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ8VC98RUO
AbbexaPLEKHA6abx539038Mouse Pleckstrin homology domain-containing family A member 6 (PLEKHA6) ELISA KitMouseSerum,Plasma,Tissue homogenates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ7TQG1RUO
AbbexaPLEKHA7abx539040Mouse Pleckstrin homology domain-containing family A member 7 (PLEKHA7) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ3UIL6RUO
AbbexaPLEKHA8abx539044Mouse Pleckstrin homology domain-containing family A member 8 (PLEKHA8) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ80W71RUO
AbbexaPLEKHA4abx539035Rat Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) ELISA KitRatTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsP60669RUO
AbbexaPLEKHA8abx539045Rat Pleckstrin Homology Domain Containing A8 (PLEKHA8) ELISA KitRatTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsD3ZY60RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
AbbexaPLEKHA5abx430809Pleckstrin Homology Domain Containing A5 (PLEKHA5) AntibodyPolyclonalGoatPleckstrin Homology Domain Containing A5 (PLEKHA5)UnconjugatedP-ELISA250200 µlRUO
FineTestPLEKHA1FNab06534anti- PLEKHA1 antibodyhumanpolyclonalRabbitpleckstrin homology domain containing, family A(phosphoinositide binding specific) member 1IgGUnconjugatedELISA, WB, IHC100µgQ9HB21RUO
FineTestPLEKHA3FNab06535anti- PLEKHA3 antibodyhumanpolyclonalRabbitpleckstrin homology domain containing, family A(phosphoinositide binding specific) member 3IgGUnconjugatedELISA, WB100µgQ9HB20RUO
FineTestPLEKHA5FNab06536anti- PLEKHA5 antibodyhumanpolyclonalRabbitpleckstrin homology domain containing, family A member 5IgGUnconjugatedELISA, WB100µgQ9HAU0RUO
FineTestPLEKHA8FNab06537anti- PLEKHA8 antibodyhumanpolyclonalRabbitpleckstrin homology domain containing, family A(phosphoinositide binding specific) member 8IgGUnconjugatedELISA, WB, IHC100µgQ96JA3RUO
FineTestPLEKHA8P1FNab06538anti- PLEKHA9 antibodyhumanpolyclonalRabbitpleckstrin homology domain containing, family A(phosphoinositide binding specific) member 9IgGUnconjugatedELISA, WB100µgO95397RUO
AbbexaPLEKHA1abx321937Pleckstrin Homology Domain Containing A1 (PLEKHA1) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A1 (PLEKHA1)UnconjugatedELISA, WB, IHC25050 µlQ9HB21RUO
AbbexaPLEKHA1abx402486Pleckstrin homology domain-containing family A member 1 (PLEKHA1) AntibodyHumanMonoclonalRabbitPleckstrin homology domain-containing family A member 1 (PLEKHA1)UnconjugatedELISA, WB287.550 µlQ9HB21RUO
AbbexaPLEKHA1abx030118Pleckstrin Homology Domain Containing A1 (PLEKHA1) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A1 (PLEKHA1)UnconjugatedELISA, WB25080 µlQ9HB21RUO
AbbexaPLEKHA1abx321051Pleckstrin Homology Domain Containing A1 (PLEKHA1) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A1 (PLEKHA1)UnconjugatedELISA, IHC25050 µlQ9HB21RUO
AbbexaPLEKHA1abx104679Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaPLEKHA1abx114542Pleckstrin Homology Domain Containing A1 (PLEKHA1) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A1 (PLEKHA1)UnconjugatedELISA, WB, IHC612.5100 µlQ9HB21RUO
AbbexaPLEKHA1abx236534Pleckstrin Homology Domain Containing A1 (PLEKHA1) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A1 (PLEKHA1)UnconjugatedELISA, WB, IHC350100 µgQ9HB21RUO
AbbexaPLEKHA3abx114543Pleckstrin Homology Domain Containing A3 (PLEKHA3) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A3 (PLEKHA3)UnconjugatedELISA, WB612.5100 µlQ9HB20RUO
AbbexaPLEKHA3abx236535Pleckstrin Homology Domain Containing A3 (PLEKHA3) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A3 (PLEKHA3)UnconjugatedELISA, WB350100 µgQ9HB20RUO
AbbexaPLEKHA4abx026435Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4)UnconjugatedELISA, WB, IHC, FCM25080 µlQ9H4M7RUO
AbbexaPLEKHA5abx236536Pleckstrin Homology Domain Containing A5 (PLEKHA5) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A5 (PLEKHA5)UnconjugatedELISA, WB350100 µgQ9HAU0RUO
AbbexaPLEKHA5abx114546Pleckstrin Homology Domain Containing A5 (PLEKHA5) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A5 (PLEKHA5)UnconjugatedELISA, WB612.5100 µlQ9HAU0RUO
AbbexaPLEKHA6abx029805Pleckstrin Homology Domain-Containing Family A Member 6 (PLEKHA6) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain-Containing Family A Member 6 (PLEKHA6)UnconjugatedELISA, WB25080 µlQ9Y2H5RUO
AbbexaPLEKHA7abx300996Pleckstrin Homology Domain-Containing Family A Member 7 (PLEKHA7) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain-Containing Family A Member 7 (PLEKHA7)UnconjugatedELISA, IF/ICC162.520 µgQ6IQ23RUO
AbbexaPLEKHA7abx314541PLEKHA7 Antibody (Biotin)HumanPolyclonalRabbitPLEKHA7BiotinELISA162.520 µgQ6IQ23RUO
AbbexaPLEKHA7abx314539PLEKHA7 Antibody (HRP)HumanPolyclonalRabbitPLEKHA7HRPELISA162.520 µgQ6IQ23RUO
AbbexaPLEKHA7abx314540PLEKHA7 Antibody (FITC)HumanPolyclonalRabbitPLEKHA7FITC162.520 µgQ6IQ23RUO
AbbexaPLEKHA8abx310473Pleckstrin Homology Domain Containing A8 (PLEKHA8) Antibody (FITC)HumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)FITC162.520 µgQ96JA3RUO
AbbexaPLEKHA8abx030189Pleckstrin Homology Domain Containing A8 (PLEKHA8) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)UnconjugatedELISA, WB281.2580 µlQ96JA3RUO
AbbexaPLEKHA8abx036146Pleckstrin Homology Domain Containing A8 (PLEKHA8) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaPLEKHA8abx310474Pleckstrin Homology Domain Containing A8 (PLEKHA8) Antibody (Biotin)HumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)BiotinELISA162.520 µgQ96JA3RUO
AbbexaPLEKHA8abx310472Pleckstrin Homology Domain Containing A8 (PLEKHA8) Antibody (HRP)HumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)HRPELISA162.520 µgQ96JA3RUO
AbbexaPLEKHA8abx318411Pleckstrin Homology Domain Containing A8 (PLEKHA8) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)UnconjugatedELISA, WB, IHC162.520 µgQ96JA3RUO
AbbexaPLEKHA8abx114544Pleckstrin Homology Domain Containing A8 (Plekha8) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (Plekha8)UnconjugatedELISA, WB, IHC612.5100 µlQ96JA3RUO
AbbexaPLEKHA8abx236537Pleckstrin Homology Domain Containing A8 (PLEKHA8) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 (PLEKHA8)UnconjugatedELISA, WB, IHC350100 µgQ96JA3RUO
AbbexaPLEKHA8P1abx036997Pleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaPLEKHA8P1abx114545Pleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9)UnconjugatedELISA, WB612.5100 µlO95397RUO
AbbexaPLEKHA8P1abx236538Pleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9) AntibodyHumanPolyclonalRabbitPleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9)UnconjugatedELISA, WB350100 µgO95397RUO
AbbexaPLEKHA1abx129422Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) AntibodyMousePolyclonalRabbitPleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1)UnconjugatedWB, IHC, IF/ICC275100 µlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaPLEKHA1abx068604Human Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) ProteinHumanE. coliUnconjugatedWB, SDS-PAGE22510 µgQ9HB21RUO
AbbexaPLEKHA1abx168385Mouse Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgRUO

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