Mouse Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) Protein

Background

PLEKHA1 is a pleckstrin homology (PH) domain-containing protein that binds to phosphoinositides, particularly phosphatidylinositol 3-phosphate (PI3P), to regulate intracellular signaling and membrane trafficking. It plays a role in endosomal sorting, vesicle transport, and cellular localization of signaling proteins, linking membrane lipids to downstream effectors. PLEKHA1 is expressed in various tissues, including immune cells and epithelial tissues, where it participates in pathways controlling cell signaling, migration, and vesicular dynamics. Emerging evidence suggests that PLEKHA1 is involved in autophagy and receptor internalization processes, particularly in response to growth factor stimulation. Dysregulation of PLEKHA1 has been implicated in cancer progression and immune dysfunction due to defects in endosomal signaling and protein trafficking. Knockdown studies reveal disrupted endosome formation, impaired membrane dynamics, and altered cellular signaling, underscoring its role in phosphoinositide-mediated cellular processes and intracellular trafficking.