Human Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA Kit

Name: Human Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA Kit
Brand: Abbexa
SKU: abx539033
Price: 715 EUR
Availability: OnlineOnly

Este producto es parte de PLEKHA - Pleckstrin homology domain containing A1

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PLEKHA4

proveedor

Abbexa

reference

abx539033

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Pleckstrin homology domain-containing family A member 4 (PLEKHA4) concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

PLEKHA4 is a pleckstrin homology (PH) domain-containing protein that binds phosphoinositides, primarily PI(4,5)P2, to localize at plasma and endosomal membranes where it regulates intracellular signaling and membrane trafficking. It plays an important role in the Wnt/β-catenin signaling pathway by interacting with components like Dishevelled proteins, influencing cellular processes such as proliferation, differentiation, and development. PLEKHA4 is expressed in epithelial and immune tissues, where it is involved in actin cytoskeleton remodeling, cell polarity, and vesicular dynamics. Dysregulation of PLEKHA4 has been linked to cancer progression, particularly melanoma, where it enhances Wnt signaling and promotes tumor cell proliferation and migration. Knockdown studies show disrupted Wnt signaling, impaired membrane localization, and defects in actin organization, highlighting its role in phosphoinositide-mediated signaling and cytoskeletal regulation during development and tumorigenesis.

Características del producto

immunogen target

Pleckstrin homology domain-containing family A member 4 (PLEKHA4)

reactivity

Human

test range

0.156 ng/ml - 10 ng/ml

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

alias

PEPP1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

PLEKHA4

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q9H4M7

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) Antibody

proveedor

Abbexa

reference

abx026435

Tested Applications

ELISA, WB, IHC, FCM

reactivity

Human

status

RUO

clonality

Polyclonal

PLEKHA4 binds specifically to phosphatidylinositol-3-phosphate (PtdIns3P), but not to other phosphoinositides.

292.5€ (80 µl)