Human Pleckstrin homology domain-containing family A member 7 (PLEKHA7) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Pleckstrin homology domain-containing family A member 7 (PLEKHA7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx539039
tested applications
ELISA
Description
Human Pleckstrin homology domain-containing family A member 7 (PLEKHA7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Pleckstrin homology domain-containing family A member 7 (PLEKHA7) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Pleckstrin homology domain-containing family A member 7 (PLEKHA7) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6IQ23 |
| OMIM | 612686 |
| Alias | PH domain-containing family A member 7 |
| Background | Elisa kits for PLEKHA7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PLEKHA7 is a pleckstrin homology (PH) domain-containing protein that localizes at adherens junctions in epithelial cells, where it plays a critical role in maintaining cell-cell adhesion and epithelial polarity. It interacts with junctional proteins like E-cadherin and components of the cytoskeleton to stabilize cell junctions, supporting tissue organization and barrier integrity. PLEKHA7 is involved in the regulation of Rho GTPase activity, influencing actin cytoskeleton dynamics and cell signaling pathways that control adhesion and migration. It is widely expressed in epithelial tissues, particularly in organs such as the intestine and kidney, where it contributes to tissue homeostasis and repair. Dysregulation or loss of PLEKHA7 has been associated with cancer progression, where disrupted cell junctions promote epithelial-mesenchymal transition (EMT), tumor invasion, and metastasis. Knockdown studies reveal impaired adherens junctions, reduced epithelial polarity, and increased cell motility, highlighting its essential role in maintaining epithelial integrity and suppressing tumorigenesis.
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