Pleckstrin Homology Domain Containing A5 (PLEKHA5) Antibody
364€ (100 µg)
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935106861
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name
Pleckstrin Homology Domain Containing A5 (PLEKHA5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236536
tested applications
ELISA, WB
Description
PLEKHA5 Antibody is a Rabbit Polyclonal against PLEKHA5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pleckstrin Homology Domain Containing A5 (PLEKHA5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HAU0 |
| Gene ID | 54477 |
| OMIM | 607770 |
| Alias | PLEKHA5, KIAA1686, PEPP2,PH domain-containing family A member 5,Phosphoinositol 3-phosphate-binding protein 2 |
| Background | Antibody anti-PLEKHA5 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PLEKHA5 is a lipid-binding adaptor protein that contains a pleckstrin homology (PH) domain, allowing it to interact with specific phosphoinositides, such as PI(3,4)P2 and PI(4,5)P2, at cellular membranes. It plays a role in intracellular trafficking, cell migration, and signal transduction, linking phosphoinositide dynamics to cytoskeletal reorganization and membrane recruitment of signaling proteins. PLEKHA5 is highly expressed in brain and neuronal tissues, where it participates in processes like synaptic signaling, axon guidance, and neuronal migration. Dysregulation of PLEKHA5 is associated with metastatic melanoma, where it enhances tumor cell invasion and migration through actin remodeling and signaling pathways like PI3K/Akt. Functional studies show that depletion of PLEKHA5 reduces metastatic potential and disrupts membrane-associated signaling, underscoring its role in cell polarity, phosphoinositide signaling, and cancer progression.
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