PLEKHA3 antibody
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935106861
info@markelab.com
name
PLEKHA3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06535
tested applications
ELISA, WB
Description
Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate(PtdIns4P).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | pleckstrin homology domain containing, family A(phosphoinositide binding specific) member 3 (PLEKHA3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 34 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9HB20 |
| Gene ID | 65977 |
| Alias | FAPP1,PH domain-containing family A member 3,Phosphatidylinositol-four-phosphate adapter protein 1 |
| Background | Antibody anti-PLEKHA3 |
| Status | RUO |
| Note | Mol. Weight 34 kDa |
Descripción
PLEKHA3 is a member of the pleckstrin homology (PH) domain-containing protein family that binds phosphoinositides, including PI(3,4)P2 and PI(4,5)P2, to regulate membrane targeting and intracellular signaling pathways. It is involved in processes such as cell polarity, membrane trafficking, and cytoskeletal organization, where it recruits signaling complexes to membrane compartments. PLEKHA3 is expressed in various tissues, including immune and epithelial cells, where it regulates endocytic vesicle transport, signal transduction, and cellular adhesion. It has been implicated in processes like epithelial-mesenchymal transition (EMT) and cancer progression, where its dysregulation promotes cell migration, invasion, and altered signaling dynamics. Knockdown studies reveal defects in endocytosis, impaired membrane recruitment of signaling proteins, and disrupted cytoskeletal organization, underscoring its critical role in phosphoinositide-mediated cellular signaling, vesicular trafficking, and cell polarity.
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