Rat Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) ELISA Kit
715€ (96 tests)
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name
Rat Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx539035
tested applications
ELISA
Description
Rat Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Pleckstrin homology domain-containing family A member 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Pleckstrin Homology Domain-Containing Family A Member 4 (PLEKHA4) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P60669 |
| Alias | PEPP1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1 |
| Background | Elisa kits for PLEKHA4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PLEKHA4 is a pleckstrin homology (PH) domain-containing protein that binds phosphoinositides, primarily PI(4,5)P2, to localize at plasma and endosomal membranes where it regulates intracellular signaling and membrane trafficking. It plays an important role in the Wnt/β-catenin signaling pathway by interacting with components like Dishevelled proteins, influencing cellular processes such as proliferation, differentiation, and development. PLEKHA4 is expressed in epithelial and immune tissues, where it is involved in actin cytoskeleton remodeling, cell polarity, and vesicular dynamics. Dysregulation of PLEKHA4 has been linked to cancer progression, particularly melanoma, where it enhances Wnt signaling and promotes tumor cell proliferation and migration. Knockdown studies show disrupted Wnt signaling, impaired membrane localization, and defects in actin organization, highlighting its role in phosphoinositide-mediated signaling and cytoskeletal regulation during development and tumorigenesis.
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