PLEKHA1 antibody
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Name
PLEKHA1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab06534
Tested Applications
ELISA, WB, IHC
Description
Binds specifically to phosphatidylinositol 3,4-diphosphate(PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | pleckstrin homology domain containing, family A(phosphoinositide binding specific) member 1 (PLEKHA1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 46 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9HB21 |
| Gene ID | 59338 |
| Alias | PLEKHA1, TAPP1, PH domain-containing family A member 1,Tandem PH domain-containing protein 1 |
| Background | Antibody anti-PLEKHA1 |
| Status | RUO |
| Note | Mol. Weight 46 kDa |
Background
PLEKHA1 is a pleckstrin homology (PH) domain-containing protein that binds to phosphoinositides, particularly phosphatidylinositol 3-phosphate (PI3P), to regulate intracellular signaling and membrane trafficking. It plays a role in endosomal sorting, vesicle transport, and cellular localization of signaling proteins, linking membrane lipids to downstream effectors. PLEKHA1 is expressed in various tissues, including immune cells and epithelial tissues, where it participates in pathways controlling cell signaling, migration, and vesicular dynamics. Emerging evidence suggests that PLEKHA1 is involved in autophagy and receptor internalization processes, particularly in response to growth factor stimulation. Dysregulation of PLEKHA1 has been implicated in cancer progression and immune dysfunction due to defects in endosomal signaling and protein trafficking. Knockdown studies reveal disrupted endosome formation, impaired membrane dynamics, and altered cellular signaling, underscoring its role in phosphoinositide-mediated cellular processes and intracellular trafficking.
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