Pleckstrin Homology Domain Containing A3 (PLEKHA3) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Pleckstrin Homology Domain Containing A3 (PLEKHA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx114543
tested applications
ELISA, WB
Description
Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 3 Antibody is a Rabbit Polyclonal antibody against Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pleckstrin Homology Domain Containing A3 (PLEKHA3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HB20 |
| Gene ID | 65977 |
| OMIM | 607774 |
| Alias | FAPP1,PH domain-containing family A member 3,Phosphatidylinositol-four-phosphate adapter protein 1 |
| Background | Antibody anti-PLEKHA3 |
| Status | RUO |
Descripción
PLEKHA3 is a member of the pleckstrin homology (PH) domain-containing protein family that binds phosphoinositides, including PI(3,4)P2 and PI(4,5)P2, to regulate membrane targeting and intracellular signaling pathways. It is involved in processes such as cell polarity, membrane trafficking, and cytoskeletal organization, where it recruits signaling complexes to membrane compartments. PLEKHA3 is expressed in various tissues, including immune and epithelial cells, where it regulates endocytic vesicle transport, signal transduction, and cellular adhesion. It has been implicated in processes like epithelial-mesenchymal transition (EMT) and cancer progression, where its dysregulation promotes cell migration, invasion, and altered signaling dynamics. Knockdown studies reveal defects in endocytosis, impaired membrane recruitment of signaling proteins, and disrupted cytoskeletal organization, underscoring its critical role in phosphoinositide-mediated cellular signaling, vesicular trafficking, and cell polarity.
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