Human Pleckstrin Homology Domain Containing A3 (PLEKHA3) ELISA Kit

Este producto es parte de PLEKHA - Pleckstrin homology domain containing A1
Human Pleckstrin Homology Domain Containing A3 (PLEKHA3) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PLEKHA3

proveedor

Abbexa

reference

abx382285

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Pleckstrin Homology Domain Containing A3 (PLEKHA3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PLEKHA3 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PLEKHA3 is a member of the pleckstrin homology (PH) domain-containing protein family that binds phosphoinositides, including PI(3,4)P2 and PI(4,5)P2, to regulate membrane targeting and intracellular signaling pathways. It is involved in processes such as cell polarity, membrane trafficking, and cytoskeletal organization, where it recruits signaling complexes to membrane compartments. PLEKHA3 is expressed in various tissues, including immune and epithelial cells, where it regulates endocytic vesicle transport, signal transduction, and cellular adhesion. It has been implicated in processes like epithelial-mesenchymal transition (EMT) and cancer progression, where its dysregulation promotes cell migration, invasion, and altered signaling dynamics. Knockdown studies reveal defects in endocytosis, impaired membrane recruitment of signaling proteins, and disrupted cytoskeletal organization, underscoring its critical role in phosphoinositide-mediated cellular signaling, vesicular trafficking, and cell polarity.

Características del producto

category

ELISA Kits


immunogen target

Pleckstrin Homology Domain Containing A3 (PLEKHA3)


reactivity

Human


test range

0.313 ng/ml - 20 ng/ml


sensitivity

< 0.188 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

FAPP1,PH domain-containing family A member 3,Phosphatidylinositol-four-phosphate adapter protein 1 


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PLEKHA3


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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