Human Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) Protein

Este producto es parte de PLEKHA - Pleckstrin homology domain containing A1
Human Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) Protein
234€ (10 µg)

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Name
Human Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068604
Tested Applications
WB, SDS-PAGE

Description

Human Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Leu92-Glu346
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 32.5 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q9HB21
Alias
PLEKHA1, TAPP1, PH domain-containing family A member 1,Tandem PH domain-containing protein 1
Background
Protein PLEKHA1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

PLEKHA1 is a pleckstrin homology (PH) domain-containing protein that binds to phosphoinositides, particularly phosphatidylinositol 3-phosphate (PI3P), to regulate intracellular signaling and membrane trafficking. It plays a role in endosomal sorting, vesicle transport, and cellular localization of signaling proteins, linking membrane lipids to downstream effectors. PLEKHA1 is expressed in various tissues, including immune cells and epithelial tissues, where it participates in pathways controlling cell signaling, migration, and vesicular dynamics. Emerging evidence suggests that PLEKHA1 is involved in autophagy and receptor internalization processes, particularly in response to growth factor stimulation. Dysregulation of PLEKHA1 has been implicated in cancer progression and immune dysfunction due to defects in endosomal signaling and protein trafficking. Knockdown studies reveal disrupted endosome formation, impaired membrane dynamics, and altered cellular signaling, underscoring its role in phosphoinositide-mediated cellular processes and intracellular trafficking.

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