Human Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein PLEKHA1
proveedor
Abbexareference
abx068604Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
PLEKHA1 is a pleckstrin homology (PH) domain-containing protein that binds to phosphoinositides, particularly phosphatidylinositol 3-phosphate (PI3P), to regulate intracellular signaling and membrane trafficking. It plays a role in endosomal sorting, vesicle transport, and cellular localization of signaling proteins, linking membrane lipids to downstream effectors. PLEKHA1 is expressed in various tissues, including immune cells and epithelial tissues, where it participates in pathways controlling cell signaling, migration, and vesicular dynamics. Emerging evidence suggests that PLEKHA1 is involved in autophagy and receptor internalization processes, particularly in response to growth factor stimulation. Dysregulation of PLEKHA1 has been implicated in cancer progression and immune dysfunction due to defects in endosomal signaling and protein trafficking. Knockdown studies reveal disrupted endosome formation, impaired membrane dynamics, and altered cellular signaling, underscoring its role in phosphoinositide-mediated cellular processes and intracellular trafficking.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu92-Glu346 Tag: N-terminal His tag
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
PLEKHA1
dry ice
No
availability
Shipped within 5-7 working days.
alias
PLEKHA1, TAPP1, PH domain-containing family A member 1,Tandem PH domain-containing protein 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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