Human Pleckstrin Homology Domain Containing A5 (PLEKHA5) ELISA Kit

Este producto es parte de PLEKHA - Pleckstrin homology domain containing A1
Human Pleckstrin Homology Domain Containing A5 (PLEKHA5) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PLEKHA5

proveedor

Abbexa

reference

abx382286

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Pleckstrin Homology Domain Containing A5 (PLEKHA5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PLEKHA5 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PLEKHA5 is a lipid-binding adaptor protein that contains a pleckstrin homology (PH) domain, allowing it to interact with specific phosphoinositides, such as PI(3,4)P2 and PI(4,5)P2, at cellular membranes. It plays a role in intracellular trafficking, cell migration, and signal transduction, linking phosphoinositide dynamics to cytoskeletal reorganization and membrane recruitment of signaling proteins. PLEKHA5 is highly expressed in brain and neuronal tissues, where it participates in processes like synaptic signaling, axon guidance, and neuronal migration. Dysregulation of PLEKHA5 is associated with metastatic melanoma, where it enhances tumor cell invasion and migration through actin remodeling and signaling pathways like PI3K/Akt. Functional studies show that depletion of PLEKHA5 reduces metastatic potential and disrupts membrane-associated signaling, underscoring its role in cell polarity, phosphoinositide signaling, and cancer progression.

Características del producto

category

ELISA Kits


immunogen target

Pleckstrin Homology Domain Containing A5 (PLEKHA5)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

PLEKHA5, KIAA1686, PEPP2,PH domain-containing family A member 5,Phosphoinositol 3-phosphate-binding protein 2


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PLEKHA5


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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