Human Pleckstrin Homology Domain Containing A5 (PLEKHA5) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PLEKHA5
proveedor
Abbexareference
abx382286Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Pleckstrin Homology Domain Containing A5 (PLEKHA5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PLEKHA5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PLEKHA5 is a lipid-binding adaptor protein that contains a pleckstrin homology (PH) domain, allowing it to interact with specific phosphoinositides, such as PI(3,4)P2 and PI(4,5)P2, at cellular membranes. It plays a role in intracellular trafficking, cell migration, and signal transduction, linking phosphoinositide dynamics to cytoskeletal reorganization and membrane recruitment of signaling proteins. PLEKHA5 is highly expressed in brain and neuronal tissues, where it participates in processes like synaptic signaling, axon guidance, and neuronal migration. Dysregulation of PLEKHA5 is associated with metastatic melanoma, where it enhances tumor cell invasion and migration through actin remodeling and signaling pathways like PI3K/Akt. Functional studies show that depletion of PLEKHA5 reduces metastatic potential and disrupts membrane-associated signaling, underscoring its role in cell polarity, phosphoinositide signaling, and cancer progression.
Características del producto
category
ELISA Kits
immunogen target
Pleckstrin Homology Domain Containing A5 (PLEKHA5)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.094 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PLEKHA5, KIAA1686, PEPP2,PH domain-containing family A member 5,Phosphoinositol 3-phosphate-binding protein 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PLEKHA5
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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