Mouse Pleckstrin homology domain-containing family A member 2 (PLEKHA2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PLEKHA2
proveedor
Abbexareference
abx539030Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Pleckstrin homology domain-containing family A member 2 (PLEKHA2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Pleckstrin homology domain-containing family A member 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PLEKHA2 is a lipid-binding protein that contains a pleckstrin homology (PH) domain with high specificity for phosphoinositides such as PI(3,4)P2, enabling it to localize to plasma membranes and mediate signaling events. It plays a key role in actin cytoskeletal dynamics, cellular migration, and immune cell signaling by recruiting cytoskeletal regulators and signaling molecules to membrane sites. PLEKHA2 is expressed in immune and endothelial cells, where it regulates processes such as phagocytosis, chemotaxis, and membrane ruffling during immune responses. It also participates in signaling pathways like PI3K/Akt, contributing to cell survival and proliferation. Dysregulation of PLEKHA2 has been associated with inflammatory diseases and cancer metastasis due to altered actin remodeling and immune cell dysfunction. Knockout studies demonstrate impaired actin polymerization, reduced immune cell migration, and defects in membrane organization, highlighting its role as a mediator of phosphoinositide-driven cellular responses.
Características del producto
category
ELISA Kits
immunogen target
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
TAPP2,PH domain-containing family A member 2,Tandem PH domain-containing protein 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PLEKHA2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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