Pleckstrin Homology Domain-Containing Family A Member 7 (PLEKHA7) Antibody
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Pleckstrin Homology Domain-Containing Family A Member 7 (PLEKHA7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx300996
tested applications
ELISA, IF/ICC
Description
PLEKHA7 Antibody is a Rabbit Polyclonal against PLEKHA7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pleckstrin Homology Domain-Containing Family A Member 7 (PLEKHA7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6IQ23 |
| Gene ID | 144100 |
| NCBI Accession | NP_001316559.1, NM_001329630.1, NP_001316560.1, NM_001329631.1 |
| OMIM | 612686 |
| Alias | PH domain-containing family A member 7 |
| Background | Antibody anti-PLEKHA7 |
| Status | RUO |
Descripción
PLEKHA7 is a pleckstrin homology (PH) domain-containing protein that localizes at adherens junctions in epithelial cells, where it plays a critical role in maintaining cell-cell adhesion and epithelial polarity. It interacts with junctional proteins like E-cadherin and components of the cytoskeleton to stabilize cell junctions, supporting tissue organization and barrier integrity. PLEKHA7 is involved in the regulation of Rho GTPase activity, influencing actin cytoskeleton dynamics and cell signaling pathways that control adhesion and migration. It is widely expressed in epithelial tissues, particularly in organs such as the intestine and kidney, where it contributes to tissue homeostasis and repair. Dysregulation or loss of PLEKHA7 has been associated with cancer progression, where disrupted cell junctions promote epithelial-mesenchymal transition (EMT), tumor invasion, and metastasis. Knockdown studies reveal impaired adherens junctions, reduced epithelial polarity, and increased cell motility, highlighting its essential role in maintaining epithelial integrity and suppressing tumorigenesis.
Related Products
Pleckstrin Homology Domain-Containing Family A Member 7 (PLEKHA7) Antibody
PLEKHA7 Antibody is a Rabbit Polyclonal against PLEKHA7.
Ver ProductoPLEKHA7 Antibody (HRP)
PLEKHA7 Antibody (HRP) is a Rabbit Polyclonal against PLEKHA7 conjugated to HRP.
Ver Producto
PLEKHA7 Antibody (FITC)
PLEKHA7 Antibody (FITC) is a Rabbit Polyclonal against PLEKHA7 conjugated to FITC.
Ver Producto