Pleckstrin Homology Domain Containing A5 (PLEKHA5) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Pleckstrin Homology Domain Containing A5 (PLEKHA5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx114546
tested applications
ELISA, WB
Description
Pleckstrin Homology Domain Containing, Family A Member 5 Antibody is a Rabbit Polyclonal antibody against Pleckstrin Homology Domain Containing, Family A Member 5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pleckstrin Homology Domain Containing A5 (PLEKHA5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HAU0 |
| Gene ID | 54477 |
| NCBI Accession | NM_019012.5 |
| OMIM | 607770 |
| Alias | PLEKHA5, KIAA1686, PEPP2,PH domain-containing family A member 5,Phosphoinositol 3-phosphate-binding protein 2 |
| Background | Antibody anti-PLEKHA5 |
| Status | RUO |
Descripción
PLEKHA5 is a lipid-binding adaptor protein that contains a pleckstrin homology (PH) domain, allowing it to interact with specific phosphoinositides, such as PI(3,4)P2 and PI(4,5)P2, at cellular membranes. It plays a role in intracellular trafficking, cell migration, and signal transduction, linking phosphoinositide dynamics to cytoskeletal reorganization and membrane recruitment of signaling proteins. PLEKHA5 is highly expressed in brain and neuronal tissues, where it participates in processes like synaptic signaling, axon guidance, and neuronal migration. Dysregulation of PLEKHA5 is associated with metastatic melanoma, where it enhances tumor cell invasion and migration through actin remodeling and signaling pathways like PI3K/Akt. Functional studies show that depletion of PLEKHA5 reduces metastatic potential and disrupts membrane-associated signaling, underscoring its role in cell polarity, phosphoinositide signaling, and cancer progression.
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