Mouse Pleckstrin homology domain-containing family A member 8 (PLEKHA8) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PLEKHA8
proveedor
Abbexareference
abx539044Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Pleckstrin homology domain-containing family A member 8 (PLEKHA8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Pleckstrin homology domain-containing family A member 8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PLEKHA8, also known as TAPP1 (tandem PH-domain-containing protein 1), is a phosphoinositide-binding protein that interacts with PI(3,4)P2 to regulate intracellular trafficking and endosomal sorting processes. It functions in the recruitment of signaling complexes to membrane compartments, facilitating endocytosis, vesicle transport, and cellular polarity. PLEKHA8 is expressed in a variety of tissues, including epithelial cells, neurons, and immune cells, where it contributes to processes such as membrane dynamics, actin reorganization, and signal transduction. It plays an essential role in endosomal trafficking pathways, ensuring proper receptor recycling and signaling molecule localization. Dysregulation of PLEKHA8 has been implicated in cancer and neurodevelopmental disorders, where impaired membrane trafficking and signaling disrupt cell polarity and migration. Knockdown studies demonstrate defects in vesicular transport, reduced phosphoinositide binding, and altered cellular polarity, underscoring its critical role in intracellular trafficking and phosphoinositide-mediated signaling.
Características del producto
category
ELISA Kits
immunogen target
Pleckstrin homology domain-containing family A member 8 (PLEKHA8)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
FAPP2,PH domain-containing family A member 8,Phosphatidylinositol-four-phosphate adapter protein 2,FAPP-2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PLEKHA8
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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