Human Pleckstrin Homology Domain Containing A8 (PLEKHA8) ELISA Kit

Este producto es parte de PLEKHA - Pleckstrin homology domain containing A1
Human Pleckstrin Homology Domain Containing A8 (PLEKHA8) ELISA Kit
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Human Pleckstrin Homology Domain Containing A8 (PLEKHA8) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx382287
Tested Applications
ELISA

Description

Human Pleckstrin Homology Domain Containing A8 (PLEKHA8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PLEKHA8 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Pleckstrin Homology Domain Containing A8 (PLEKHA8)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.313 ng/ml - 20 ng/ml
Sensitivity
< 0.188 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q96JA3
Gene ID
84725
OMIM
608639
Alias
FAPP2,PH domain-containing family A member 8,Phosphatidylinositol-four-phosphate adapter protein 2,FAPP-2
Background
Elisa Kits for: PLEKHA8
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

PLEKHA8, also known as TAPP1 (tandem PH-domain-containing protein 1), is a phosphoinositide-binding protein that interacts with PI(3,4)P2 to regulate intracellular trafficking and endosomal sorting processes. It functions in the recruitment of signaling complexes to membrane compartments, facilitating endocytosis, vesicle transport, and cellular polarity. PLEKHA8 is expressed in a variety of tissues, including epithelial cells, neurons, and immune cells, where it contributes to processes such as membrane dynamics, actin reorganization, and signal transduction. It plays an essential role in endosomal trafficking pathways, ensuring proper receptor recycling and signaling molecule localization. Dysregulation of PLEKHA8 has been implicated in cancer and neurodevelopmental disorders, where impaired membrane trafficking and signaling disrupt cell polarity and migration. Knockdown studies demonstrate defects in vesicular transport, reduced phosphoinositide binding, and altered cellular polarity, underscoring its critical role in intracellular trafficking and phosphoinositide-mediated signaling.

Productos relacionados

abx030189

Pleckstrin Homology Domain Containing A8 (PLEKHA8) Antibody

PLEKHA8 is involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. May pl…

Ver producto
abx036146

Pleckstrin Homology Domain Containing A8 (PLEKHA8) Antibody

Rabbit Polyclonal against the PLEKHA8 protein.…

Ver producto
abx114544

Pleckstrin Homology Domain Containing A8 (Plekha8) Antibody

Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 8 Antibody is a Rabbit Polycl…

Ver producto