Pleckstrin Homology Domain-Containing Family A Member 6 (PLEKHA6) Antibody

Background

PLEKHA6 is a member of the pleckstrin homology (PH) domain-containing protein family that interacts with phosphoinositides, enabling its recruitment to plasma and endosomal membranes for the regulation of intracellular signaling and vesicle trafficking. It functions as a scaffold protein that coordinates the localization and activity of signaling molecules involved in cytoskeletal dynamics, endocytosis, and cellular adhesion. PLEKHA6 is expressed in epithelial, endothelial, and immune cells, where it regulates processes like cell migration, polarity, and tissue remodeling. Dysregulation of PLEKHA6 has been implicated in cancer metastasis and inflammatory disorders due to its role in actin reorganization and cell adhesion dynamics. Knockout studies demonstrate defects in membrane trafficking, impaired cellular adhesion, and reduced migration, highlighting its essential role in coordinating phosphoinositide-mediated signaling pathways, cytoskeletal organization, and cellular polarity.