Pleckstrin Homology Domain Containing A8 Pseudogene 1 (PLEKHA9) Antibody

Background

Pleckstrin homology domain-containing A8 pseudogene 1 (PLEKHA8P1) is a pseudogene derived from the parent gene PLEKHA8, which encodes a protein involved in membrane trafficking and phosphoinositide binding, particularly associated with intracellular vesicle dynamics and signaling pathways. Although PLEKHA8P1 lacks the ability to code for a functional protein, it may still play a regulatory role through mechanisms such as transcriptional interference, RNA-mediated regulation, or serving as a competing endogenous RNA to modulate the availability of microRNAs targeting its parental gene or related pathways. Pseudogenes like PLEKHA8P1 are increasingly recognized for their potential contributions to gene expression regulation and genome evolution, often serving as reservoirs of genetic diversity or influencing neighboring gene activity. PLEKHA8P1 has been implicated in studies exploring its expression patterns in specific tissues or disease states, with some evidence suggesting its dysregulation may correlate with pathological conditions, including cancer, where it might influence cellular signaling indirectly. Further investigation is required to elucidate its precise functional roles and potential contributions to the regulatory networks involving PLEKHA8 and other pleckstrin homology domain-containing proteins.