Human Pleckstrin Homology Domain Containing A1 (PLEKHA1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PLEKHA1
proveedor
Abbexareference
abx382284Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Pleckstrin Homology Domain Containing A1 (PLEKHA1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PLEKHA1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PLEKHA1 is a pleckstrin homology (PH) domain-containing protein that binds to phosphoinositides, particularly phosphatidylinositol 3-phosphate (PI3P), to regulate intracellular signaling and membrane trafficking. It plays a role in endosomal sorting, vesicle transport, and cellular localization of signaling proteins, linking membrane lipids to downstream effectors. PLEKHA1 is expressed in various tissues, including immune cells and epithelial tissues, where it participates in pathways controlling cell signaling, migration, and vesicular dynamics. Emerging evidence suggests that PLEKHA1 is involved in autophagy and receptor internalization processes, particularly in response to growth factor stimulation. Dysregulation of PLEKHA1 has been implicated in cancer progression and immune dysfunction due to defects in endosomal signaling and protein trafficking. Knockdown studies reveal disrupted endosome formation, impaired membrane dynamics, and altered cellular signaling, underscoring its role in phosphoinositide-mediated cellular processes and intracellular trafficking.
Características del producto
category
ELISA Kits
immunogen target
Pleckstrin Homology Domain Containing A1 (PLEKHA1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.094 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PLEKHA1, TAPP1, PH domain-containing family A member 1,Tandem PH domain-containing protein 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PLEKHA1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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