Human Pleckstrin Homology Domain Containing A1 (PLEKHA1) ELISA Kit

Este producto es parte de PLEKHA - Pleckstrin homology domain containing A1
Human Pleckstrin Homology Domain Containing A1 (PLEKHA1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PLEKHA1

proveedor

Abbexa

reference

abx382284

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Pleckstrin Homology Domain Containing A1 (PLEKHA1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PLEKHA1 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PLEKHA1 is a pleckstrin homology (PH) domain-containing protein that binds to phosphoinositides, particularly phosphatidylinositol 3-phosphate (PI3P), to regulate intracellular signaling and membrane trafficking. It plays a role in endosomal sorting, vesicle transport, and cellular localization of signaling proteins, linking membrane lipids to downstream effectors. PLEKHA1 is expressed in various tissues, including immune cells and epithelial tissues, where it participates in pathways controlling cell signaling, migration, and vesicular dynamics. Emerging evidence suggests that PLEKHA1 is involved in autophagy and receptor internalization processes, particularly in response to growth factor stimulation. Dysregulation of PLEKHA1 has been implicated in cancer progression and immune dysfunction due to defects in endosomal signaling and protein trafficking. Knockdown studies reveal disrupted endosome formation, impaired membrane dynamics, and altered cellular signaling, underscoring its role in phosphoinositide-mediated cellular processes and intracellular trafficking.

Características del producto

category

ELISA Kits


immunogen target

Pleckstrin Homology Domain Containing A1 (PLEKHA1)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

PLEKHA1, TAPP1, PH domain-containing family A member 1,Tandem PH domain-containing protein 1


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PLEKHA1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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